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Alli orlistat weight loss pills; 1,4-dioxetidine, also known as Zantac; 3,4-diphenyl-1-propane-1,3-dione; 4-amino-3-methylglutaryl-glycine; and 3,4-dihydroxy-5-methoxy-4-hydroxy-phenyl 2,5-dihydro-3H-tetrahydro-4-sulfonic acid acetate, are considered potential candidates for treatment. These medications have been investigated for long-term weight loss. Three randomized trials and open-label were orlistat xenical capsules performed. In one trial, 3,4-dihydroxy-5-methoxy-4-hydroxy-phenyl 2,5-dihydro-3H-tetrahydro-4-sulfonic acid acetate was administered for 24 weeks to 556 overweight patients who were seeking weight loss. Those who had a 50% reduction of body weight by at least three months and who had no metabolic syndrome traits showed the most significant gain in weight loss at six months (1,738 +/- 48 Kg) and the most significant loss of 2.5 kg at twelve months (1,738 +/- 56 Kg) (Figure 9C). A similar effect was observed in a second trial when 3,4-dihydroxy-5-methoxy-4-hydroxy-phenyl 2,5-dihydro-3H-tetrahydro-4-sulfonic acid acetate was administered to 1,564 obese patients who were seeking weight loss. Those who had a 25% or less reduction of body weight achieved more significant loss than those with a 100% reduction of body weight (1,739 +/- 67 Kg) (Figure 9D). These two trials were discontinued early due to unexpected weight regain in the Orlistat 120mg $209.97 - $7 Per pill controlled groups, spite of fact that they were powered to show benefit. In a third trial, 3,4-dihydroxy-5-methoxy-4-hydroxy-phenyl 2,5-dihydro-3H-tetrahydro-4-sulfonic acid acetate was administered for 24 weeks to 1,895 overweight men and women in a randomized, double-blind fashion. As compared with placebo, a significant improvement in body weight was observed at six months and twelve months. At six months, weight loss was 1,819 +/- 73 Kg and 1,927 77 with placebo 3,4-dihydroxy-5-methoxy-4-hydroxy-phenyl 2,5-dihydro-3H-tetrahydro-4-sulfonic acid acetate (1,819 +/- 69 Kg) (Figure 9E) (1). FIGURE 9. View largeDownload slide Effect of 3,4-Dihydroxy-5-methoxy-4-hydroxy-phenyl 2,5-dihydro-3H-tetrahydro-4-sulfonic acid and placebo on body weight (A) and percentage fat (%) in overweight men and women a randomized, double-blind fashion. B,Brief summary of 3,4-Dihydroxy-5-methoxy-4-hydroxy-phenyl 2,5-dihydro-3H-tetrahydro-4-sulfonic acid and placebo: 1.6 g per day for 3 weeks. 2,8 g of 3,4-Dihydroxy-5-methoxy-4-hydroxy-phenyl orlistat capsules 120 mg dosage 2,5-dihydro-3H-tetrahydro-4-sulfonic acid or placebo daily for 24 weeks. C,D. Percentage of body fat changes from baseline in obese (B), overweight (C) and normal-weight (D) men women. All results are means ± SE; n = 6 for placebo, 5 3,4-Dihydroxy-5-methoxy-4-hydroxy-phenyl 2,5-dihydro-3H-tetrahydro-4-sulfonic acid, n = 5 for 3,4-dihydroxy-5-methoxy-4-hydroxy-phenyl 2,5-dihydro-3H-tetrahydro-4-sulfonic acid and n = 4 for placebo. *P < 0.05 compared with placebo; **P < 0.01 compared with body weight lost without therapy (B&D).



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